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  • ISBN-10 ‏ : ‎ 0323639089
  • ISBN-13 ‏ : ‎ 978-0323639088
  • Author:  Sue Huether, Kathryn McCance

Make difficult pathophysiology concepts come to life! Filled with vibrant illustrations, simplified language, and detailed online content Understanding Pathophysiology, 7th Edition delivers the most accurate information on treatments, manifestations, and mechanisms of disease across the lifespan.This new edition is fully revised and includes coverage of rare diseases and epigenetics to you with a thorough understanding of conditions affecting the human body. Plus, with over 30 new 3D animations on the companion Evolve site, quick check boxes at the end of each chapter, and disease progression algorithms, this text helps you engage with the fundamental knowledge you need to succeed in nursing school and in practice.

 

Table of Content:

  1. Part 1 Basic Concepts of Pathophysiology
  2. Unit 1 The Cell
  3. 1 Cellular Biology
  4. Prokaryotes and Eukaryotes
  5. Cellular Functions
  6. Structure and Function of Cellular Components
  7. Cell-to-Cell Adhesions
  8. Cellular Communication and Signal Transduction
  9. Cellular Metabolism
  10. Membrane Transport: Cellular Intake and Output
  11. Cellular Reproduction: The Cell Cycle
  12. Tissues
  13. Summary Review
  14. Key Terms
  15. References
  16. 2 Genes and Genetic Diseases
  17. DNA, RNA, and Proteins: Heredity at the Molecular Level
  18. Chromosomes
  19. Elements of Formal Genetics
  20. Transmission of Genetic Diseases
  21. Linkage Analysis and Gene Mapping
  22. Multifactorial Inheritance
  23. Summary Review
  24. Key Terms
  25. References
  26. 3 Epigenetics and Disease
  27. Epigenetic Mechanisms
  28. Epigenetics and Human Development
  29. Epigenetics in Genomic Imprinting
  30. Environmental Impacts on Epigenetic Information
  31. Epigenetics and Cancer
  32. Future Directions
  33. Summary Review
  34. Key Terms
  35. References
  36. Additional Readings
  37. 4 Altered Cellular and Tissue Biology
  38. Cellular Adaptation
  39. Cellular Injury
  40. Manifestations of Cellular Injury
  41. Cellular Death
  42. Aging and Altered Cellular and Tissue Biology
  43. Somatic Death
  44. Summary Review
  45. Key Terms
  46. References
  47. 5 Fluids and Electrolytes, Acids and Bases
  48. Distribution of Body Fluids and Electrolytes
  49. Alterations in Water Movement
  50. Sodium, Chloride, and Water Balance
  51. Alterations in Sodium, Chloride, and Water Balance
  52. Alterations in Potassium and Other Electrolytes
  53. Acid–Base Balance
  54. Pediatric Considerations
  55. Geriatric Considerations
  56. Summary Review
  57. Key Terms
  58. References
  59. Unit 2 Mechanisms of Self-Defense
  60. 6 Innate Immunity
  61. Human Defense Mechanisms
  62. Innate Immunity
  63. Acute and Chronic Inflammation
  64. Wound Healing
  65. Pediatric Considerations
  66. Geriatric Considerations
  67. Summary Review
  68. Key Terms
  69. References
  70. 7 Adaptive Immunity
  71. Overview of Adaptive Immunity
  72. Antigens and Immunogens
  73. Immune Response: Collaboration of B Cells and T Cells
  74. Humoral Immunity (Antibodies)
  75. Cell-Mediated Immunity
  76. Pediatric Considerations
  77. Geriatric Considerations
  78. Summary Review
  79. Key Terms
  80. References
  81. 8 Alterations in Immunity
  82. Hypersensitivity Reactions
  83. Immunologic Mechanisms of Hypersensitivity Reactions
  84. Deficiencies in Immunity
  85. Secondary (Acquired) Immune Deficiencies
  86. Summary Review
  87. Key Terms
  88. References
  89. 9 Infection
  90. Microorganisms and Humans: a Dynamic Relationship
  91. Infectious Disease
  92. Antibiotic/Antimicrobial Resistance
  93. Vaccines and Protection Against Infection
  94. Summary Review
  95. Key Terms
  96. References
  97. 10 Stress and Disease
  98. Background and General Concepts of Stress
  99. The Stress Systems
  100. Chronic Stress at an Early Age Increases the Risk of Developing Long-Lasting Pathophysiologic Alterations Linked to Poor Health and to Disease
  101. Negative Effects of Stress on Telomere Length, Aging, and Disease
  102. Coping and Intervention Strategies
  103. Summary Review
  104. Key Terms
  105. References
  106. Unit 3 Cellular Proliferation: Cancer
  107. 11 Cancer Biology
  108. Cancer Terminology and Characteristics
  109. The Biology of Cancer Cells
  110. Clinical Manifestations of Cancer
  111. Diagnosis and Staging of Cancer
  112. Treatment of Cancer
  113. Summary Review
  114. Key Terms
  115. References
  116. 12 Cancer Epidemiology
  117. Genetics, Epigenetics, and Tissue
  118. In Utero and Early Life Conditions
  119. Environmental-Lifestyle Factors
  120. Summary Review
  121. Key Terms
  122. References
  123. 13 Cancer in Children and Adolescents
  124. Incidence, Etiology, and Types of Childhood Cancer
  125. Prognosis
  126. Summary Review
  127. Key Terms
  128. References
  129. Part 2 Body Systems and Diseases
  130. Unit 4 The Neurologic System
  131. 14 Structure and Function of the Neurologic System
  132. Overview and Organization of the Nervous System
  133. Cells of the Nervous System
  134. The Nerve Impulse
  135. Central Nervous System
  136. Blood Supply
  137. Peripheral Nervous System
  138. Autonomic Nervous System
  139. Geriatric Considerations
  140. Summary Review
  141. Key Terms
  142. References
  143. 15 Pain, Temperature, Sleep, and Sensory Function
  144. Pain
  145. Temperature Regulation
  146. Sleep
  147. The Special Senses
  148. Geriatric Considerations
  149. Geriatric Considerations
  150. Somatosensory Function
  151. Summary Review
  152. Key Terms
  153. References
  154. 16 Alterations in Cognitive Systems, Cerebral Hemodynamics, and Motor Function
  155. Alterations in Cognitive Systems
  156. Alterations in Cerebral Hemodynamics
  157. Alterations in Neuromotor Function
  158. Alterations in Complex Motor Performance
  159. Extrapyramidal Motor Syndromes
  160. Summary Review
  161. Key Terms
  162. References
  163. 17 Disorders of the Central and Peripheral Nervous Systems and Neuromuscular Junction
  164. Central Nervous System Disorders
  165. Peripheral Nervous System and Neuromuscular Junction Disorders
  166. Tumors of the Central Nervous System
  167. Summary Review
  168. Key Terms
  169. References
  170. 18 Alterations of Neurologic Function in Children
  171. Development of the Nervous System in Children
  172. Structural Malformations
  173. Alterations in Function: Encephalopathies
  174. Cerebrovascular Disease in Children
  175. Childhood Tumors
  176. Summary Review
  177. Key Terms
  178. References
  179. Unit 5 The Endocrine System
  180. 19 Mechanisms of Hormonal Regulation
  181. Mechanisms of Hormonal Regulation
  182. Structure and Function of the Endocrine Glands
  183. Geriatric Considerations
  184. Summary Review
  185. Key Terms
  186. References
  187. 20 Alterations of Hormonal Regulation
  188. Mechanisms of Hormonal Alterations
  189. Alterations of the Hypothalamic–Pituitary System
  190. Alterations of Thyroid Function
  191. Alterations of Parathyroid Function
  192. Dysfunction of the Endocrine Pancreas: Diabetes Mellitus
  193. Alterations of Adrenal Function
  194. Summary Review
  195. Key Terms
  196. References
  197. 21 Obesity, Starvation, and Anorexia of Aging
  198. Adipose Tissue
  199. Obesity
  200. Starvation
  201. Anorexia of Aging
  202. Summary Review
  203. Key Terms
  204. References
  205. Unit 6 The Hematologic System
  206. 22 Structure and Function of the Hematologic System
  207. Components of the Hematologic System
  208. Development of Blood Cells
  209. Mechanisms of Hemostasis
  210. Pediatrics and Blood
  211. Aging and Blood
  212. Summary Review
  213. Key Terms
  214. References
  215. 23 Alterations of Hematologic Function
  216. Anemia
  217. Myeloproliferative Red Cell Disorders
  218. Alterations of Leukocyte Function
  219. Alterations of Lymphoid Function
  220. Alterations of Splenic Function
  221. Hemorrhagic Disorders and Alterations of Platelets and Coagulation
  222. Summary Review
  223. Key Terms
  224. References
  225. 24 Alterations of Hematologic Function in Children
  226. Disorders of Erythrocytes
  227. Disorders of Coagulation and Platelets
  228. Neoplastic Disorders
  229. Summary Review
  230. Key Terms
  231. References
  232. Unit 7 The Cardiovascular and Lymphatic Systems
  233. 25 Structure and Function of the Cardiovascular and Lymphatic Systems
  234. Circulatory System
  235. Heart
  236. Systemic Circulation
  237. The Lymphatic System
  238. Summary Review
  239. Key Terms
  240. References
  241. 26 Alterations of Cardiovascular Function
  242. Diseases of the Veins
  243. Diseases of the Arteries
  244. Disorders of the Heart Wall
  245. Manifestations of Heart Disease
  246. Shock
  247. Summary Review
  248. Key Terms
  249. References
  250. 27 Alterations of Cardiovascular Function in Children
  251. Congenital Heart Disease
  252. Acquired Cardiovascular Disorders
  253. Summary Review
  254. Key Terms
  255. References
  256. Unit 8 The Pulmonary System
  257. 28 Structure and Function of the Pulmonary System
  258. Structures of the Pulmonary System
  259. Function of the Pulmonary System
  260. Geriatric Considerations
  261. Summary Review
  262. Key Terms
  263. References
  264. 29 Alterations of Pulmonary Function
  265. Clinical Manifestations of Pulmonary Alterations
  266. Pulmonary Disorders
  267. Summary Review
  268. Key Terms
  269. References
  270. 30 Alterations of Pulmonary Function in Children
  271. Disorders of the Upper Airways
  272. Disorders of the Lower Airways
  273. Sudden Infant Death Syndrome
  274. Summary Review
  275. Key Terms
  276. References
  277. Unit 9 The Renal and Urologic Systems
  278. 31 Structure and Function of the Renal and Urologic Systems
  279. Structures of the Renal System
  280. Renal Blood Flow and Glomerular Filtration
  281. Kidney Function
  282. Tests of Renal Function
  283. Pediatric Considerations
  284. Geriatric Considerations
  285. Summary Review
  286. Key Terms
  287. References
  288. 32 Alterations of Renal and Urinary Tract Function
  289. Urinary Tract Obstruction
  290. Urinary Tract Infection
  291. Glomerular Disorders
  292. Acute Kidney Injury
  293. Chronic Kidney Disease
  294. Summary Review
  295. Key Terms
  296. References
  297. 33 Alterations of Renal and Urinary Tract Function in Children
  298. Structural Abnormalities
  299. Glomerular Disorders
  300. Nephroblastoma
  301. Bladder Disorders
  302. Urinary Incontinence
  303. Summary Review
  304. Key Terms
  305. References
  306. Unit 10 The Reproductive Systems
  307. 34 Structure and Function of the Reproductive Systems
  308. Development of the Reproductive Systems
  309. The Female Reproductive System
  310. Structure and Function of the Breast
  311. The Male Reproductive System
  312. Aging and Reproductive Function
  313. Summary Review
  314. Key Terms
  315. References
  316. 35 Alterations of the Female Reproductive System
  317. Abnormalities of the Female Reproductive Tract
  318. Alterations of Sexual Maturation
  319. Disorders of the Female Reproductive System
  320. Disorders of the Female Breast
  321. Summary Review
  322. Key Terms
  323. References
  324. 36 Alterations of the Male Reproductive System
  325. Alterations of Sexual Maturation
  326. Disorders of the Male Reproductive System
  327. References
  328. Disorders of the Male Breast
  329. Sexually Transmitted Infections
  330. Summary Review
  331. Key Terms
  332. References
  333. Unit 11 The Digestive System
  334. 37 Structure and Function of the Digestive System
  335. The Gastrointestinal Tract
  336. Accessory Organs of Digestion
  337. Geriatric Considerations
  338. Summary Review
  339. Key Terms
  340. References
  341. 38 Alterations of Digestive Function
  342. Disorders of the Gastrointestinal Tract
  343. Disorders of the Accessory Organs of Digestion
  344. Cancer of the Digestive System
  345. Summary Review
  346. Key Terms
  347. References
  348. 39 Alterations of Digestive Function in Children
  349. Congenital Impairment of Motility in the Gastrointestinal Tract
  350. Acquired Impairment of Motility in the Gastrointestinal Tract
  351. Impairment of Digestion, Absorption, and Nutrition
  352. Diarrhea
  353. Disorders of the Liver
  354. Summary Review
  355. Key Terms
  356. References
  357. Unit 12 The Musculoskeletal and Integumentary Systems
  358. 40 Structure and Function of the Musculoskeletal System
  359. Structure and Function of Bones
  360. Structure and Function of Joints
  361. Structure and Function of Skeletal Muscles
  362. Aging & the Musculoskeletal System
  363. Summary Review
  364. Key Terms
  365. References
  366. 41 Alterations of Musculoskeletal Function
  367. Musculoskeletal Injuries
  368. Disorders of Bones
  369. Disorders of Joints
  370. References
  371. Disorders of Skeletal Muscle
  372. Musculoskeletal Tumors
  373. Summary Review
  374. Key Terms
  375. References
  376. 42 Alterations of Musculoskeletal Function in Children
  377. Congenital Defects
  378. Bone and Joint Infection
  379. Juvenile Idiopathic Arthritis
  380. Osteochondroses
  381. Scoliosis
  382. Neuromuscular Disorders
  383. Musculoskeletal Tumors
  384. Nonaccidental Trauma
  385. Summary Review
  386. Key Terms
  387. References
  388. 43 Structure, Function, and Disorders of the Integument
  389. Structure and Function of the Skin
  390. Disorders of the Skin
  391. Disorders of the Hair
  392. Disorders of the Nail
  393. Geriatric Considerations
  394. Summary Review
  395. Key Terms
  396. References
  397. 44 Alterations of the Integument in Children
  398. Acne Vulgaris
  399. Dermatitis
  400. Infections of the Skin
  401. Insect Bites and Parasites
  402. Cutaneous Hemangiomas and Vascular Malformations
  403. Other Skin Disorders
  404. Summary Review
  405. Key Terms
  406. References
  407. Index
  408. Prefixes and Suffixes Used in Medical Terminology
  409. Word Roots Commonly Used in Medical Terminology

 

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